|Phone - 919-668-1584|
Bryan Alzheimer's Disease Research Center
2200 West Main Street
Duke University Medical Center
Durham, NC 27705
Department of Psychiatry & Behavioral Sciences
Division of Geriatric Psychiatry
My research is focused on several areas with the central theme of early detection of cognitive changes and risk factors associated with the development of Alzheimer‘s disease (AD) and other dementias. Current areas of investigation are a) the epidemiology of cognitive decline and mild cognitive impairment due to AD, b) the study of cognitive endophenotypes, c) genetic risk factors for late onset AD, and d) the development of statistical methods to model cognitive profiles as they manifest at early stages of disease.
Recent work on endophenotyping (pre-clinical cognitive profiles) utilized data from the National Alzheimer’s Coordinating Centers (NACC) study. This is a national, longitudinal effort to collect standardized data, including risk factors, diagnoses, and DNA, from Alzheimer’s Disease Centers (ADCs) across the US (see resource page for more information).
PhD, Johns Hopkins University, 2004
Hayden KM, McEvoy JM, Linnertz C, et al: A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging. Alzheimers Dement 2012; 8:381-388.
Hayden KM,Welsh-Bohmer KA: Epidemiology of Cognitive Aging and Alzheimer's Disease: Contributions of the Cache County Utah Study of Memory, Health and Aging. Curr Top Behav Neurosci 201.
Hayden KM, Reed BR, Manly JJ, et al: Cognitive decline in the elderly: an analysis of population heterogeneity. Age and ageing 2011.
Hayden KM, Jones RN, Zimmer C, et al: Factor Structure of the National Alzheimer's Coordinating Centers Uniform Dataset Neuropsychological Battery: An Evaluation of Invariance Between and Within Groups Over Time. Alzheimer Dis Assoc Disord 2011; 25:128-137.