Ornit Chiba-Falek, Ph.D.
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Ornit Chiba-Falek, Ph.D.

Phone - 919-681-8001

GSRB I, Room 2005
905 S. LaSalle Street
Box 3445
Duke University Medical Center
Durham, NC 277010
email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Assistant Professor
Department of Medicine
Division of Neurology
Research Description

My primary goal is to gain insight into the genetic factors and molecular mechanisms underlying age-related complex neurological disorders, in particular cognitive decline and dementia, and Lewy body diseases.  Currently, our research program employs functional genomics approaches to studying non-coding regulatory variants within disease-associated regions in the human genome, with focus on Alzheimer’s and Parkinson’s diseases.


Ph.D., Genetics, Hebrew University, Jerusalem, Israel, 1999

B.Sc., Biology, Hebrew University, Jerusalem, Israel, 1994

Recent Publications

McCarthy JJ, Linnertz C, Saucier L, Burke JR, Hulette CM, Welsh-Bohmer KA and Chiba-Falek O. (2011) The Effect of SNCA 3' Region on the Levels of SNCA-112 Splicing Variant.  Neurogenetics 12(1)59-64. PMCID:PMC3030669

McCarthy JJ, Saith S, Linnertz C, Burke JR, Hulette CM, Welsh-Bohmer KA and Chiba-Falek O. (2012) The Alzheimer's associated 5' region of the SORL1 gene cis-regulates SORL1 transcripts expression. Neurobiology of Aging 33(7):1485.e1-8. PMCID:PMC3117021

Linnertz C,  Saunders AM, Lutz MW, Crenshaw DM, Grossman I, Burns DK, Whitfield KE, Hauser MA, McCarthy JJ, Ulmer M, Allingham R, Welsh-Bohmer KA, Roses AD and Chiba-Falek O.  (2012) Characterization of the Poly-T Variant in the TOMM40 Gene in Diverse Populations. PLoS ONE 7(2):e30994. PMCID: PMC3281049

Hayden KM, McEvoy JM, Colton Linnertz C, Attix D, Kuchibhatla M, Saunders AM, Lutz MW, Welsh-Bohmer KA, Roses AD and Chiba-Falek O. (2012) A homopolymer polymorphism in the  TOMM40 gene contributes to cognitive performance in aging. Alzheimer’s and Dementia [Epub ahead of print].

Chiba-Falek O, Linnertz C, Guyton J, Gardner SD, Roses AD, McCarthy JJ, Patel K. (2012) Pleiotropy and
allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection. Hum Genet [Epub ahead of print].

Link to Dr. Chiba-Falek's web page @ Neurology