Carl Pieper, DrPH
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Carl Pieper, Ph.D.

Phone - 919-660-7525

0508 Busse Bldg Durham, NC  27710
Box 3003
Duke University Medical Center
Durham, NC 27710

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Assistant Professor
Biostat & Bioinformatics Chairs Office

Research Description

Analytic Interests:
1) Issues in the Design of Medical Experiments: I explore the use of reliability/generalizability models in experimental design. In addition to incorporation of reliability, I study powering longitudinal trials with multiple outcomes and substantial missing data using Mixed models.
2) Issues in the Analysis of Repeated Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed Models in modeling trajectories of multiple variables over time (e.g., physical and cognitive functioning and blood pressure). My current work involves methodologies in simultaneous estimation of trajectories for multiple variables within and between domains, modeling co-occuring change.

Areas of Substantive interest:
(1) Experimental design and analysis in gerontology and geriatrics, and psychiatry,
(2) Multivariate repeated measures designs.


DrPH, Columbia University, 1990

MPH, Columbia Univeristy, 1983

BS, Duke University, 1975

Recent Publications

Colón-Emeric CS, Mesenbrink P, Lyles KW, Pieper CF, Boonen S, Delmas P, Eriksen EF, Magaziner J. Potential Mediators of the Mortality Reduction with Zoledronic Acid After Hip Fracture. J Bone Miner Res. 2009 Jul 6.

Eriksen EF, Lyles KW, Colón-Emeric CS, Pieper CF, Magaziner JS, Adachi JD, Hyldstrup L, Recknor C, Nordsletten L, Lavecchia C, Hu H, Boonen S, Mesenbrink P. Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. J Bone Miner Res. 2009 Jul;24(7):1308-13.

Hulette CM, Ervin JF, Edmonds Y, Antoine S, Stewart N, Szymanski MH, Hayden KM, Pieper CF, Burke JR, Welsh-Bohmer KA. Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease. J Neuropathol Exp Neurol. 2009 Apr;68(4):417-24.