Mirta Mihovilovic, Ph.D.
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Phone - 919-684-0063

245 Bryan Research Building
Box 2900
Duke University Medical Center
Durham, NC 27710

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Research Scientist, Senior
Department of Medicine
Division of Neurology

Research Description

Currently, Dr. Mihovilovic’s studies are directed at defining the biochemical consequences associated with the TOMM40 poly T “523” polymorphism in Alzheimer’s disease.  In the prior 12 years, she has studied the biochemical bases of pathologies associated with different APOE genotypes.

Earlier in her career, Dr. Mihovilovic was involved in the characterization of proteins and, in particular,  the analysis of structural-functional  relationships of nicotinic acetyl choline receptors including those expressed in immune cells.  This research led her to investigate mechanisms operational in autoimmune conditions with a strong focus  on Myasthenia Gravis.

Education

PhD, Biochemistry and Biophysics, Notre Dame University, 1980

MS, Biochemistry, Notre Dame University, 1977

BS, Biochemistry, Universidad de Chile, Santiago, Chile, 1970

Recent Publications

DeKroon, R.,. M., Mihovilovic, M., Goodger, Z. V., Robinette, J. B., Sullivan, P. M., Saunders, A. M. and Strttmatter, W. J. Apoliprotein E genotype-specific inhibition of apoptosis. J. Lip. Res. 44:1566-1573 (2003).

DeKroon, R., Robinette, J. B., Hjelmeland, A. B., Wiiggins, E., Blackwell, M., Mihovilovic, M., Fujii, M., York, J., Hart, J., Kontos, C., Rich, J. and Strittmatter, W. J. APOE4-VLDL inhibits the HDL-activated phosphatidylinositol-3-kinase/Akt pathway via the phosphoinositol phosphatase SHIP2. Cir. Res. 99:829-836 (2006).

Mihovilovic, M., Robinette, J. B., DeKroon, R., Sullivan, P. M. and Strittmatter, W. J. High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J. Lip. Res. 48:806-815 (2007).

Weinberg, J. B., Volkheimer, A. D., Mihovilovic, M., Jiang, n., Chen, Yuwei., Bond, K., Moore, J.O., Gockerman, J. P., Diehl, L. f., deCastro, C. M., Rizzieri, D. A., Levesque, M. C., DeKroon, R. and Stritmatter, W.J. Apolipoprotein E genotype as a determinant of survival in women with chronic lymphocytic leukemia. Leukemia. 22:2184-2192 (2008).

Zhao, Q., Choi, E., Hockley, J., Mihovilovic, M., Xu, Q., Vasek, M., Vitek, M., and Colton, C. Apolipoprotein E interacts with Estrogen Receptor to modulate ER activity in neuronal cells. Journal of Neuroscience, submitted.