Phone - 919-684-0063
245 Bryan Research Building
Duke University Medical Center
Durham, NC 27710
|Research Scientist, Senior|
Department of Medicine
Division of Neurology
Currently, Dr. Mihovilovic’s studies are directed at defining the biochemical consequences associated with the TOMM40 poly T “523” polymorphism in Alzheimer’s disease. In the prior 12 years, she has studied the biochemical bases of pathologies associated with different APOE genotypes.
Earlier in her career, Dr. Mihovilovic was involved in the characterization of proteins and, in particular, the analysis of structural-functional relationships of nicotinic acetyl choline receptors including those expressed in immune cells. This research led her to investigate mechanisms operational in autoimmune conditions with a strong focus on Myasthenia Gravis.
PhD, Biochemistry and Biophysics, Notre Dame University, 1980
MS, Biochemistry, Notre Dame University, 1977
BS, Biochemistry, Universidad de Chile, Santiago, Chile, 1970
DeKroon, R.,. M., Mihovilovic, M., Goodger, Z. V., Robinette, J. B., Sullivan, P. M., Saunders, A. M. and Strttmatter, W. J. Apoliprotein E genotype-specific inhibition of apoptosis. J. Lip. Res. 44:1566-1573 (2003).
DeKroon, R., Robinette, J. B., Hjelmeland, A. B., Wiiggins, E., Blackwell, M., Mihovilovic, M., Fujii, M., York, J., Hart, J., Kontos, C., Rich, J. and Strittmatter, W. J. APOE4-VLDL inhibits the HDL-activated phosphatidylinositol-3-kinase/Akt pathway via the phosphoinositol phosphatase SHIP2. Cir. Res. 99:829-836 (2006).
Mihovilovic, M., Robinette, J. B., DeKroon, R., Sullivan, P. M. and Strittmatter, W. J. High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J. Lip. Res. 48:806-815 (2007).
Weinberg, J. B., Volkheimer, A. D., Mihovilovic, M., Jiang, n., Chen, Yuwei., Bond, K., Moore, J.O., Gockerman, J. P., Diehl, L. f., deCastro, C. M., Rizzieri, D. A., Levesque, M. C., DeKroon, R. and Stritmatter, W.J. Apolipoprotein E genotype as a determinant of survival in women with chronic lymphocytic leukemia. Leukemia. 22:2184-2192 (2008).
Zhao, Q., Choi, E., Hockley, J., Mihovilovic, M., Xu, Q., Vasek, M., Vitek, M., and Colton, C. Apolipoprotein E interacts with Estrogen Receptor to modulate ER activity in neuronal cells. Journal of Neuroscience, submitted.