Michael Lutz, Ph.D.
Home Team Center Directory
Phone - 919-660-7621

Bryan Alzheimer's Disease Research Center
2200 West Main Street
Suite A-200
Duke University Medical Center
Durham, NC 27705

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Senior Research Scientist
Department of Medicine
Division of Neurology

Research Description

Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease.   Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease.

PhD, Biomedical Engineering, Duke University, 1986

BS, Biomedical Engineering, Duke University, 1981

Recent Publications

Caselli RJ, Dueck AC, Huentelman MJ, Lutz MW, Saunders AM, Reiman EM and Roses AD (2012) Longitudinal Modelings of Cognitive Aging and the TOMM40 effect.  Alzheimer’s and Dementia 8(6):490-495.

Hayden KM, McEvoy JM, Linnertz C, Attix D, Kuchibhatla M, Saunders AM, Lutz MW, Welsh-Bohmer KA, Roses AD, Chiba-Falek O (2012) A homopolymer in the TOMM40 gene contributes to cognitive performance in aging. Alzheimer’s and Dementia 8(5):381-388.

Bruno D, Nierenberg JJ, Ritchie JC, Lutz MW and Pomara N (2011) Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants. Psychoneuroendocrinology 37(3): 366-371.
Johnson S, Sager MA, Saunders AM, Lutz MW and Roses AD (2011) The Effect of TOMM40 Poly-T length on Gray Matter Volume and Cognition in Middle-Aged Persons with APOE e3/e3 Genotype. Alzheimer’s and Dementia 7: 456-465.

Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, Huentelman MJ, Welsh-Bohmer KA and Reiman EM (2009) A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. Pharmacogenomics J. 10: 375-384.